Impact of Azidohomoalanine Incorporation on Protein Structure and Ligand Binding,ChemBioChem

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Impact of Azidohomoalanine Incorporation on Protein Structure and Ligand Binding
ChemBioChem ( IF 2.6 ) Pub Date : 2017-11-07 06:06:33 , DOI: 10.1002/cbic.201700437
Florian Lehner ₁ , Denis Kudlinzki _{1,

2} , Christian Richter ₁ , Henrike M. Müller-Werkmeister ₃ , Katharina B. Eberl ₃ , Jens Bredenbeck ₃ , Harald Schwalbe ₁ , Robert Silvers _{1,

4}

Affiliation

Unnatural influence: Unnatural amino acids are widely used to study proteins. NMR spectroscopy and X-ray diffraction are applied to characterize the structural and dynamic impact of azidohomoalanine (AZH) incorporation into the model protein PDZ3 domain. The structure and dynamics of the apo state of AZH-modified PDZ3 remains mostly unperturbed.

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