Because of its increased convenience and decreased cost, once-daily hypofractionated radiotherapy (HFX; 2.25 Gy/fraction) has been adopted over other altered-fractionation schedules in the United States for the management of early-stage glottic cancer. In our patterns-of-care analysis, we found that over 80% of patients were treated with either hypofractionation (2.25 Gy/fraction) or conventional fractionation (CFX; 2.0 Gy/fraction); utilization rates of other altered-fractionation regimens were 2.6% or less. Given the low utilization rates of fractionation schedules not recommended by the National Comprehensive Cancer Network guidelines, we did not compare other altered-fractionation schedules to CFX. Therefore, we were not able to make conclusions regarding the optimal radiotherapy treatment schedule; we could only conclude that our findings suggest that HFX is superior to CFX.

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由于其增加的便利性和降低的成本，在美国，采用每日一次超分割放疗（HFX; 2.25 Gy / fraction）取代其他改变分割方案，以治疗早期声门癌。在我们的护理模式分析中，我们发现超过80％的患者接受过低分割（2.25 Gy /部分）或常规分割（CFX； 2.0 Gy /部分）治疗；其他变更分级方案的利用率为2.6％或更低。鉴于国家综合癌症网络指南未建议的分级分离方案利用率低，因此我们没有将其他变更分级分离方案与CFX进行比较。因此，我们无法就最佳放疗方案得出结论。