We thought we knew how the heat-producing uncoupling protein 1 in brown adipose tissue was activated: by fatty acids released upon lipid droplet breakdown in the brown adipocytes. However, two studies in this issue (Schreiber et al., 2017; Shin et al., 2017) imply that this classical model may not be valid: heat can be produced in brown fat without intracellular lipolysis.

中文翻译：

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什么点燃UCP1？

我们以为我们知道棕色脂肪组织中产生热量的解偶联蛋白1是如何被激活的：在棕色脂肪细胞中脂滴分解后释放的脂肪酸。但是，此问题的两项研究（Schreiber等人，2017; Shin等人，2017）暗示这种经典模型可能无效：无需细胞内脂解就可以在棕色脂肪中产生热量。