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Chemoselective α-Methylenation of Aromatic Ketones Using the NaAuCl4/Selectfluor/DMSO System
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2017-11-07 00:00:00 , DOI: 10.1021/acs.joc.7b01790
Hongbo Zhu 1 , Xin Meng 1 , Yanhui Zhang 1 , Guang Chen 1, 2 , Ziping Cao 1, 2 , Xuejun Sun 1, 2 , Jinmao You 1, 2
Affiliation  

Gold-catalyzed chemoselective α-methylenation of aromatic ketones was developed through the use of Selectfluor as a methylenating agent. A variety of useful 1,2-disubstituted propenone derivatives can be prepared in good yields via the present protocol. This reaction features a simple operation, good functional group tolerance, and broad scope of substrates.

中文翻译:

NaAuCl 4 / Selectfluor / DMSO系统对芳族酮的化学选择性α-甲基化

通过使用Selectfluor作为亚甲基化剂,开发了金催化的芳香族酮的化学选择性α-甲基化反应。通过本方案,可以以高收率制备各种有用的1,2-二取代的丙烯酮衍生物。该反应具有操作简单,官能团耐受性好和底物范围广的特点。
更新日期:2017-11-07
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