Chemoselective α-Methylenation of Aromatic Ketones Using the NaAuCl4/Selectfluor/DMSO System,The Journal of Organic Chemistry

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Chemoselective α-Methylenation of Aromatic Ketones Using the NaAuCl4/Selectfluor/DMSO System
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2017-11-07 00:00:00 , DOI: 10.1021/acs.joc.7b01790
Hongbo Zhu ₁ , Xin Meng ₁ , Yanhui Zhang ₁ , Guang Chen _{1,

2} , Ziping Cao _{1,

2} , Xuejun Sun _{1,

2} , Jinmao You _{1,

2}

Affiliation

Gold-catalyzed chemoselective α-methylenation of aromatic ketones was developed through the use of Selectfluor as a methylenating agent. A variety of useful 1,2-disubstituted propenone derivatives can be prepared in good yields via the present protocol. This reaction features a simple operation, good functional group tolerance, and broad scope of substrates.

中文翻译：

NaAuCl ₄ / Selectfluor / DMSO系统对芳族酮的化学选择性α-甲基化

通过使用Selectfluor作为亚甲基化剂，开发了金催化的芳香族酮的化学选择性α-甲基化反应。通过本方案，可以以高收率制备各种有用的1,2-二取代的丙烯酮衍生物。该反应具有操作简单，官能团耐受性好和底物范围广的特点。

更新日期：2017-11-07

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