A possible role for Toxoplasma gondii in the etiopathogenesis of schizophrenia is supported by epidemiological studies and animal models of infection. However, recent studies attempting to link Toxoplasma to schizophrenia have yielded mixed results. We performed a nested case-control study measured serological evidence of exposure to Toxoplasma gondii in a cohort of 2052 individuals. Within this cohort, a total of 1481 individuals had a psychiatric disorder and 571 of were controls without a psychiatric disorder. We found an increased odds of Toxoplasma exposure in individuals with a recent onset of psychosis (OR 2.44, 95% Confidence Interval 1.4–4.4, p < .003). On the other hand, an increased odds of Toxoplasma exposure was not found in individuals with schizophrenia or other psychiatric disorder who did not have a recent onset of psychosis. By identifying the timing of evaluation as a variable, these findings resolve discrepancies in previous studies and suggest a temporal relationship between Toxoplasma exposure and disease onset.

弓形虫的可能作用流行病学研究和感染的动物模型支持了精神分裂症的发病机制中的“精神分裂症”。但是，最近尝试将弓形虫与精神分裂症联系起来的研究产生了不同的结果。我们进行了一项嵌套的病例对照研究，测量了2052名人群中暴露于弓形虫的血清学证据。在该队列中，共有1481人患有精神病，其中571人为无精神病的对照。我们发现近期患有精神病的个体中弓形体暴露的几率增加（OR 2.44，95％置信区间1.4-4.4，p <.003）。另一方面，在最近没有精神病发作的精神分裂症或其他精神病患者中，未发现弓形虫暴露的几率增加。