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Green synthesis of α-amino acids by electrochemical carboxylation of imines in a flow microreactor†
Reaction Chemistry & Engineering ( IF 3.4 ) Pub Date : 2017-11-07 00:00:00 , DOI: 10.1039/c7re00149e
Yang Qu 1, 2, 3, 4 , Chiaki Tsuneishi 1, 2, 3, 4 , Hiroyuki Tateno 1, 2, 3, 4 , Yoshimasa Matsumura 4, 5, 6, 7, 8 , Mahito Atobe 1, 2, 3, 4
Affiliation  

A new approach for the green synthesis of α-amino acids using electrochemical carboxylation of imines in a flow microreactor is described. This method has the major advantage of not requiring sensitive, expensive, or toxic reagents. In addition, the reaction could be conducted using single flow-through operations, without the need for sacrificial anodes and under very mild and green conditions. Our microreactor system enabled the electrochemical synthesis of N-phenylphenylglycine derivatives in good to moderate yields.

中文翻译:

在流动微反应器中通过亚胺的电化学羧化绿色合成α-氨基酸

描述了一种在流动微反应器中使用亚胺的电化学羧化绿色合成α-氨基酸的新方法。该方法的主要优点是不需要敏感,昂贵或有毒的试剂。另外,该反应可以使用单一的流通操作进行,而不需要牺牲阳极并且在非常温和和绿色的条件下进行。我们的微反应器系统使N-苯基苯基甘氨酸衍生物能够以良好至中等的产率进行电化学合成。
更新日期:2017-11-07
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