Despite ethnic differences in allele frequencies of variants in dopaminergic genes associated with dopamine D2/D3 receptor availability (D2R), no study to date has investigated the relationship between genetic ancestry and striatal D2R. Here, we show that ancestry-informative markers significantly predict dorsal striatal D2R in 117 healthy ethnically diverse residents of the New York metropolitan area using Positron Emission Tomography (PET) with [¹¹C]raclopride (P<0.0001), while correcting for age, sex, BMI, education, smoking status, and estimated socioeconomic status (ZIP codes). Effects of ethnicity on D2R were not driven by variation in dopaminergic candidate genes. Instead, candidate gene associations with striatal D2R were diminished when correcting for ancestry. These findings imply that future studies investigating D2 receptor genes should covary for genetic ancestry or study homogeneous populations. Moreover, ancestry studies on human neurobiology should control for socioeconomic differences between ethnic groups.

中文翻译：

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遗传谱系与纹状体多巴胺D2 / D3受体可用性的关联。

尽管与多巴胺D2 / D3受体可利用性（D2R）相关的多巴胺能基因变异的等位基因频率存在种族差异，但迄今为止尚无研究调查遗传血统与纹状体D2R之间的关系。在这里，我们显示，使用正电子发射断层显像（PET）结合[ ^11]，祖先信息标记可显着预测纽约都会区117名健康的不同种族居民的纹状体背侧D2R。C] raclopride（P <0.0001），同时校正年龄，性别，BMI，教育程度，吸烟状况和估计的社会经济状况（邮政编码）。种族对D2R的影响不受多巴胺能候选基因变异的驱动。相反，在校正血统时，与纹状体D2R的候选基因关联减少了。这些发现暗示，未来研究D2受体基因的研究应为遗传起源或研究同质种群而有所帮助。此外，有关人类神经生物学的祖先研究应控制种族之间的社会经济差异。