AgSbF6‐Catalyzed Tandem Reaction of 2‐Alkynylanilines with Cyclic Enynones: Efficient access to 3‐Furo[3,2‐c]chromenylindoles and Related Scaffolds,Asian Journal of Organic Chemistry

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AgSbF6‐Catalyzed Tandem Reaction of 2‐Alkynylanilines with Cyclic Enynones: Efficient access to 3‐Furo[3,2‐c]chromenylindoles and Related Scaffolds
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2017-11-17 , DOI: 10.1002/ajoc.201700511
Anuradha Dagar ₁ , Soumitra Guin ₁ , Sampak Samanta ₁

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A simple, mild, catalytic and efficient method for the straightforward synthesis of an interesting class of a range of 2‐aryl/alkyl‐substituted‐3‐(2‐aryl/alkyl‐4H‐furo[3,2‐c]chromen‐4‐yl)‐1H‐indoles in good to high yields is reported for the first time. This atom‐efficient method proceeds via AgSbF₆‐catalyzed one‐pot sequential intramolecular hydroamination (C−N bond formation) of 2‐alkynylanilines followed by Friedel–Crafts alkylation/oxa‐cyclization (creation of new C−C and C−O bonds) reaction between in situ generated 2‐substituted indoles and several cyclic enynones.

中文翻译：

AgSbF6催化的2-炔基苯胺与环烯酮的串联反应：有效地获得3-Furo [3,2-c]苯并吲哚及其相关骨架

一种简单，温和，催化和有效的方法，用于直接合成一系列有趣的2-芳基/烷基取代的3--3-（2-芳基/烷基-4 H-呋喃[3,2- c ]铬烯首次报道了高产到高产的-4-烷基）-1 H吲哚。通过AgSbF ₆催化的2-炔基苯胺单锅顺序分子内加氢胺化反应（C-N键形成），然后进行Friedel-Crafts烷基化/氧杂环化（新的C-C和C-O键的形成））原位生成的2个取代的吲哚与几个环状烯酮之间的反应。

更新日期：2017-11-17

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