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Construction of a Biomimetic Magnetosome and Its Application as a SiRNA Carrier for High‐Performance Anticancer Therapy
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2017-11-07 , DOI: 10.1002/adfm.201703326
Fan Zhang 1 , Longjian Zhao 1 , Shumin Wang 1 , Jun Yang 1 , Guihong Lu 1 , Nana Luo 2 , Xiaoyong Gao 2 , Guanghui Ma 2 , Hai-Yan Xie 1 , Wei Wei 2
Affiliation  

Precisely delivering siRNA to its target site in cancer cells is a high‐demanding but challenging task. Herein, a biomimetic magnetosome is developed using magnetic nanocluster (MNC) as the core and Arg–Gly–Asp (RGD) decorated macrophage membrane as the cloak, which is achieved via a combination of MNC synthesis, azide‐membrane engineering, electrical assembly, and click chemistry. Such a feature‐packed magnetosome enables us to gain the success of high‐performance siRNA delivery through superior stealth effect, magnetic resonance imaging, magnetic accumulation, RGD targeting, and favorable cytoplasm trafficking. As a result, target gene expression can be significantly suppressed and tumor growth is effectively inhibited, while the systemic toxicity is not notable. These results together vote the biomimetic magnetosome as a promising siRNA delivery system for anticancer therapy.

中文翻译:

仿生磁性小体的构建及其作为高性能抗癌治疗的SiRNA载体的应用

准确地将siRNA递送至癌细胞的靶位点是一项艰巨而艰巨的任务。在此,以磁性纳米团簇(MNC)为核心,以Arg–Gly–Asp(RGD)装饰的巨噬细胞膜为隐身衣开发了仿生磁小体,这是通过MNC合成,叠氮化物膜工程,电气组装,然后点击化学。这种功能丰富的磁小体使我们能够通过出色的隐身效果,磁共振成像,磁蓄积,RGD靶向和有利的细胞质运输获得高性能siRNA的成功交付。结果,可以显着抑制靶基因的表达并有效地抑制肿瘤的生长,而全身毒性并不显着。
更新日期:2017-11-07
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