Construction of a Biomimetic Magnetosome and Its Application as a SiRNA Carrier for High‐Performance Anticancer Therapy,Advanced Functional Materials

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Construction of a Biomimetic Magnetosome and Its Application as a SiRNA Carrier for High‐Performance Anticancer Therapy
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2017-11-07 , DOI: 10.1002/adfm.201703326
Fan Zhang ₁ , Longjian Zhao ₁ , Shumin Wang ₁ , Jun Yang ₁ , Guihong Lu ₁ , Nana Luo ₂ , Xiaoyong Gao ₂ , Guanghui Ma ₂ , Hai-Yan Xie ₁ , Wei Wei ₂

Affiliation

Precisely delivering siRNA to its target site in cancer cells is a high‐demanding but challenging task. Herein, a biomimetic magnetosome is developed using magnetic nanocluster (MNC) as the core and Arg–Gly–Asp (RGD) decorated macrophage membrane as the cloak, which is achieved via a combination of MNC synthesis, azide‐membrane engineering, electrical assembly, and click chemistry. Such a feature‐packed magnetosome enables us to gain the success of high‐performance siRNA delivery through superior stealth effect, magnetic resonance imaging, magnetic accumulation, RGD targeting, and favorable cytoplasm trafficking. As a result, target gene expression can be significantly suppressed and tumor growth is effectively inhibited, while the systemic toxicity is not notable. These results together vote the biomimetic magnetosome as a promising siRNA delivery system for anticancer therapy.

中文翻译：

仿生磁性小体的构建及其作为高性能抗癌治疗的SiRNA载体的应用

准确地将siRNA递送至癌细胞的靶位点是一项艰巨而艰巨的任务。在此，以磁性纳米团簇（MNC）为核心，以Arg–Gly–Asp（RGD）装饰的巨噬细胞膜为隐身衣开发了仿生磁小体，这是通过MNC合成，叠氮化物膜工程，电气组装，然后点击化学。这种功能丰富的磁小体使我们能够通过出色的隐身效果，磁共振成像，磁蓄积，RGD靶向和有利的细胞质运输获得高性能siRNA的成功交付。结果，可以显着抑制靶基因的表达并有效地抑制肿瘤的生长，而全身毒性并不显着。

更新日期：2017-11-07

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