IRF3 and type I interferons fuel a fatal response to myocardial infarction

IRF3 and type I interferons fuel a fatal response to myocardial infarction, Published online: 06 November 2017; doi:10.1038/nm.4428

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The massive cell death that occurs during myocardial infarction releases self-DNA and triggers an interferon response in infiltrating leukocytes via a cGAS–STING–IRF3 pathway. Interference with this response—either by genetic disruption of the pathway or antibody blockade of the type I interferon receptor—is beneficial in mice subjected to myocardial infarction.

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中文翻译：

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IRF3和I型干扰素助长了对心肌梗死的致命反应

IRF3和I型干扰素助长了对心肌梗死的致命反应

IRF3和I型干扰素助长了对心肌梗死的致命反应，在线发布：2017年11月6日；doi：10.1038 / nm.4428

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心肌梗死期间发生的大量细胞死亡释放出自身DNA，并通过cGAS–STING–IRF3途径触发了浸润性白细胞的干扰素反应。通过遗传途径的干扰或I型干扰素受体的抗体阻断来干扰这种反应，在遭受心肌梗塞的小鼠中是有益的。

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