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Pairing of integrins with ECM proteins determines migrasome formation
Cell Research ( IF 44.1 ) Pub Date : 2017-11-06 , DOI: 10.1038/cr.2017.108
Danni Wu , Yue Xu , Tianlun Ding , Yan Zu , Chun Yang , Li Yu

Recently we reported the discovery of migrasome, a new organelle of migrating cells1. Migrasomes are large vesicles that grow on the tips or intersections of retraction fibers at the rear of migrating cells. Following cell migration, the retraction fibers eventually break and the migrasomes become detached. The migrasomes and their contents, including cytosolic components and vesicles of unknown origin, are released into the extracellular space —— a process we named as migracytosis. We speculated that migracytosis may play important roles in cell-cell communication.

中文翻译:

整合素与ECM蛋白的配对决定了微粒体的形成

最近,我们报道了偏头痛的发现,这是一种新的细胞迁移细胞器。粒状小囊泡是生长在迁移细胞后部的回缩纤维的尖端或交叉点上的大囊泡。细胞迁移后,回缩纤维最终断裂,并使微粒体脱离。微粒体及其内容物,包括未知来源的胞质成分和囊泡,被释放到细胞外空间中-我们称其为“粒细胞增多症”。我们推测,偏头痛可能在细胞间通讯中起重要作用。
更新日期:2017-11-06
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