Every year, hundreds of tons of organic pollutants reach the environment through effluents released from wastewater treatment plants worldwide, and many of these compounds have harmful effects on the aquatic ecosystem. A new class of emerging pollutants of high concern is cytostatic drugs, which are designed to treat different types of cancers by attacking cells. Environmental concentrations of cytostatic drugs are known to be in the range of ng L⁻¹, and for this reason, it is imperative to develop analytical methods of extraction and preconcentration to allow for subsequent instrumental analysis of these drugs.

In this work, a rapid, simple and green method for the analysis of seven cytostatic drug compounds that are commonly used in anti-cancer therapies was developed using a novel extraction process based on a powerful miniaturized technique, fabric phase sorptive extraction (FPSE) coupled to ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC–MS/MS).

The major parameters that affect the extraction process were optimized. The new method shows good linearity, with a relative standard deviation (RSD) of less than 12%. Relative recoveries higher than 40% were obtained for the studied compounds, and the detection limit of the method was within the values at which these compounds are usually found in environmental water (0.20 ng L⁻¹ to 80 ng L⁻¹). The Limit of Quantification ranged from 0.68 to 267 ng L⁻¹. Significant suppression of the signal due to the matrix effect, a common shortcoming attributed to interference from the extraction process as well as the use of ionization mode, was not observed. Subsequently, the method was applied to real wastewater samples from an effluent obtained from a hospital area and three wastewater treatment plants located in Gran Canaria Island, Spain.

每年，世界各地废水处理厂释放的废水将数百吨有机污染物排放到环境中，其中许多化合物都对水生生态系统产生有害影响。引起高度关注的新型新兴污染物是细胞生长抑制药物，其旨在通过攻击细胞来治疗不同类型的癌症。已知细胞抑制药物的环境浓度在ng L ^-1范围内，因此，必须开发提取和预浓缩的分析方法，以便随后对这些药物进行仪器分析。

在这项工作中，基于一种强大的微型化技术，一种新颖的提取工艺，结合了织物相吸附提取（FPSE），开发了一种快速，简单且绿色的方法，用于分析抗癌疗法中常用的七种抑制细胞生长的药物化合物。到超高效液相色谱串联质谱（UHPLC–MS / MS）。

优化了影响提取过程的主要参数。新方法显示出良好的线性，相对标准偏差（RSD）小于12％。所研究化合物的相对回收率高于40％，该方法的检出限在环境水中通常发现的这些化合物的值范围内（0.20 ng L ^-1至80 ng L ^-1）。定量限为0.68至267 ng L ^-1。没有观察到由于基质效应对信号的显着抑制，这是归因于提取过程的干扰以及使用电离模式的共同缺点。随后，该方法应用于从医院区域和西班牙大加那利岛上的三个废水处理厂获得的废水中的真实废水样品。