We read with great interest the recent excellent work by Stevens et al ,1 in which the authors showed that zonulin and fatty acid-binding protein 2 have a relationship with the increase in lipopolysaccharide (LPS) and abnormal composition of gut microbiota in patients with anxiety or depression. We appreciate these findings and would like to discuss the role of enterochromaffin cells (ECs) in brain function in this context. Accumulating evidence has shown that neuropsychiatric diseases are frequently associated with gut microbiota disorders.2 It has been widely recognised that toxins within the human body mainly stem from the gut.3 The opening of intercellular tight junctions in the gut allow many toxins into the bloodstream that then have a deleterious effect on the brain, finally resulting in a series of neuropsychiatric symptoms. …

中文翻译：

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肠道中的肠嗜铬细胞：大脑功能的远距离调节器？

我们怀着极大的兴趣阅读了 Stevens 等人最近的出色工作 1，其中作者表明 zonulin 和脂肪酸结合蛋白 2 与焦虑患者脂多糖 (LPS) 的增加和肠道微生物群的异常组成有关或抑郁症。我们感谢这些发现，并想在这种情况下讨论肠嗜铬细胞 (EC) 在脑功能中的作用。越来越多的证据表明，神经精神疾病经常与肠道菌群紊乱有关。2 人们普遍认为，人体内的毒素主要来自肠道。3 肠道细胞间紧密连接的开放使许多毒素进入血液，然后对大脑产生有害影响，最终导致一系列神经精神症状。…