Brown adipose tissue (BAT) is responsible for adaptive non-shivering thermogenesis. Moreover, brown fat secretes regulatory factors, so-called brown adipokines, that have autocrine, paracrine, and endocrine actions. Brown adipokines are either polypeptides or nonpeptidic molecules including lipid molecules and microRNAs. The secretory properties of brown fat are essential for tissue remodeling adaptations to thermogenic necessities. The endocrine properties of brown adipokines are thought to contribute to the association between BAT activity and a healthy metabolic profile in relation to glucose and lipid homeostasis. The identification and characterization of brown adipokines may allow the discovery of circulating biomarkers of BAT activity in humans, and will lead to the development of candidate tools for therapeutic interventions in metabolic diseases.

中文翻译：

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棕色脂肪因子的生活和时代

棕色脂肪组织 (BAT) 负责适应性非颤抖产热。此外，棕色脂肪会分泌调节因子，即所谓的棕色脂肪因子，具有自分泌、旁分泌和内分泌作用。棕色脂肪因子是多肽或非肽分子，包括脂质分子和微 RNA。棕色脂肪的分泌特性对于组织重塑适应产热必需品至关重要。棕色脂肪因子的内分泌特性被认为有助于 BAT 活性与与葡萄糖和脂质稳态相关的健康代谢特征之间的关联。棕色脂肪因子的鉴定和表征可能有助于发现人类 BAT 活性的循环生物标志物，