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Retuning the Radio in Radiobiology.
Journal of the National Cancer Institute ( IF 9.9 ) Pub Date : 2018-04-01 , DOI: 10.1093/jnci/djx234
Steven J Chmura 1 , Philip P Connell 1 , Ralph R Weichselbaum 1
Affiliation  

The radiobiology research community has contributed immensely to cancer research, with far-reaching and consequential scientific insights, including demonstration that the chromosome is the target of radiation-induced mutations (Muller, Nobel prize, 1946), advances in DNA repair (Lindahl/Modrich/Sancar, Nobel prize, 2015), descriptions of hypoxia in cancer biology (first noted by Thomlinson/Gray in 1955 [1] with eventual Lasker Prize to Ratcliffe/Semenza/Kaelin, 2016), identification of stem cells (Till/McCulloch, Lasker prize in 2005), and the work of Tolmach that presaged a fuller description of cell cycles (Hartwell/Hunt/Nurse, Nobel prize, 2001). Radiobiologic discoveries have transformed scientific disciplines well beyond the field of radiobiology. Furthermore, many radiobiology principles have slowly become embedded into larger scientific pursuits and clinical practice, such as multimodality chemoradiotherapy (2–4) and cancer immunotherapy (5–7).

中文翻译:

重新调整无线电生物学中的无线电。

放射生物学研究界为癌症研究做出了巨大贡献,具有深远而重要的科学见解,包括证明染色体是辐射诱导突变的靶标(Muller,诺贝尔奖,1946年),DNA修复的进步(Lindahl / Modrich) / Sancar,2015年诺贝尔奖,癌症生物学中的缺氧描述(Thomlinson / Gray在1955年首次提出[1],并最终获得了Ratcliffe / Semenza / Kaelin的拉斯克奖,2016年),干细胞的鉴定(Till / McCulloch, 2005年获得拉斯克奖),以及托尔马赫的工作预示了细胞周期的更完整描述(哈特威尔/亨特/护士,诺贝尔奖,2001年)。放射生物学的发现已大大改变了放射生物学领域以外的科学学科。此外,
更新日期:2017-11-03
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