Compound 1 regulates significantly fewer genes than the PPARδ modulator, GW501516. Both compounds are efficacious in a thermal injury model of muscle regeneration. The restricted gene profile of 1 relative to GW501516 suggests that 1 may be pharmacoequivalent to GW501516 with fewer PPAR-related safety concerns.

中文翻译：

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与GW501516相比，高选择性过氧化物酶体增殖物激活受体δ（PPARδ）调节剂显示出改善的安全性

与PPARδ调节剂GW501516相比，化合物1调节的基因明显少得多。两种化合物在肌肉再生的热损伤模型中都是有效的。相对于GW501516而言，受限制的1个基因图谱表明1可能与GW501516在药理上等效，而与PPAR相关的安全性问题较少。