This report describes the synthesis of C-rich sequence, cytosine pentamer, of aep-PNA and its biophysical studies for the formation of hybrid DNA:aep-PNAi-motif structure with DNA cytosine pentamer (dC₅) under acidic pH conditions. Herein, the CD/UV/NMR/ESI-Mass studies strongly support the formation of stable hybrid DNA i-motif structure with aep-PNA even near acidic conditions. Hence aep-PNA C-rich sequence cytosine could be considered as potential DNA i-motif stabilizing agents in vivo conditions.

中文翻译：

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杂合DNA i-基序：氨乙基脯氨酰-PNA（pC ₅）增强了DNA（dC ₅）i-基序结构的稳定性

本报告描述C-丰富序列的合成，五聚体胞嘧啶，的AEP -PNA及其对形成杂化DNA的生物物理研究：AEP -PNAi基序结构与DNA胞嘧啶五聚体（DC ₅酸性pH条件下）。这里，CD / UV / NMR / ESI-质谱研究强烈支持稳定的杂交DNA的i-基序结构的与地层AEP -PNA即使接近酸性条件。因此AEP -PNA C-丰富序列胞嘧啶可以被认为是潜在的DNA的i-基序的稳定剂在体内的条件。