Two series of derivatives with 1,2,3-triazole as heterocyclic moiety of Jiyuan Oridonin A, a new ent-kaurene diterpenoid which was isolated from genus Isodon rubescens, were synthesized and biologically evaluated. All the derivatives possessed good anti-proliferative activities. Among them, compound 8g was found to significantly induce cell apoptosis and cell cycle arrest in MGC-803 via a series of signals activated by the increased intracellular ROS levels.

中文翻译：

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济源冬凌草甲素1,2,3-三唑衍生物的设计，合成及生物学机理研究

合成了由1,2,3-三唑作为济元冬凌草甲素A的杂环部分的两类衍生物，该衍生物是从红冬凌草（Isodon rubescens）属中分离得到的一种新的对映体-月桂烯二萜类化合物。所有衍生物均具有良好的抗增殖活性。其中，发现化合物8g通过一系列由细胞内ROS水平升高激活的信号显着诱导MGC-803中的细胞凋亡和细胞周期停滞。