Scrub typhus is a serious public health problem in the Asia-Pacific area. It threatens one billion people globally, and causes illness in one million people each year. Caused by Orientia tsutsugamushi, scrub typhus can result in severe multiorgan failure with a case fatality rate up to 70% without appropriate treatment. The antigenic heterogeneity of O. tsutsugamushi precludes generic immunity and allows reinfection. As a neglected disease, there is still a large gap in our knowledge of the disease, as evidenced by the sporadic epidemiologic data and other related public health information regarding scrub typhus in its endemic areas. Our objective is to provide a systematic analysis of current epidemiology, prevention and control of scrub typhus in its long-standing endemic areas and recently recognized foci of infection.

恙虫病是亚太地区严重的公共卫生问题。它威胁着全球 10 亿人，每年导致 100 万人患病。恙虫病由恙虫病东方体引起，如果没有适当的治疗，可导致严重的多器官衰竭，病死率高达 70%。 O的抗原异质性。恙虫病会阻碍一般免疫力并导致再次感染。作为一种被忽视的疾病，我们对该病的认识仍然存在很大差距，流行地区有关恙虫病的零星流行病学数据和其他相关公共卫生信息就证明了这一点。我们的目标是对恙虫病长期流行地区和最近发现的感染灶的当前流行病学、预防和控制进行系统分析。