Iterative Photoinduced Chain Functionalization as a Generic Platform for Advanced Polymeric Drug Delivery Systems,Macromolecular Rapid Communications

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Iterative Photoinduced Chain Functionalization as a Generic Platform for Advanced Polymeric Drug Delivery Systems
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2017-11-02 , DOI: 10.1002/marc.201700502
Assala Al Samad _{1,

2} , Audrey Bethry ₁ , Olga Janouskova ₃ , Jérémie Ciccione ₁ , Christiane Wenk ₄ , Jean-Luc Coll ₄ , Gilles Subra ₁ , Tomas Etrych ₃ , Fawaz El Omar ₂ , Youssef Bakkour ₂ , Jean Coudane ₁ , Benjamin Nottelet ₁

Affiliation

Advanced drug delivery systems (DDS) are easily designed following a photoiterative strategy. Multifunctional polymers are obtained by coupling building blocks of interest to an alkynated poly(ε‐caprolactone) (PCL) platform via an efficient thiol–yne photoaddition. Fine‐tuning over the design is achieved, as illustrated with targeting and enzyme‐responsive DDS.

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