Incorporating different data processing methods, optical coherence tomography (OCT) has the ability for high-resolution angiography and quantitative flow velocity measurements. However, OCT angiography cannot provide quantitative information of flow velocities, and the velocity measurement based on Doppler OCT requires the determination of Doppler angles, which is a challenge in a complex vascular network. In this study, we report on a relative standard deviation OCT (RSD-OCT) method which provides both vascular network mapping and quantitative information for flow velocities within a wide range of Doppler angles. The RSD values are angle-insensitive within a wide range of angles, and a nearly linear relationship was found between the RSD values and the flow velocities. The RSD-OCT measurement in a rat cortex shows that it can quantify the blood flow velocities as well as map the vascular network in vivo.

中文翻译：

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使用相对标准偏差 OCT 进行定量角度不敏感流量测量


光学相干断层扫描（OCT）结合了不同的数据处理方法，具有高分辨率血管造影和定量流速测量的能力。然而，OCT血管造影无法提供血流速度的定量信息，并且基于多普勒OCT的速度测量需要确定多普勒角度，这在复杂的血管网络中是一个挑战。在这项研究中，我们报告了一种相对标准偏差 OCT (RSD-OCT) 方法，该方法提供血管网络映射和宽范围多普勒角度内血流速度的定量信息。 RSD 值在很宽的角度范围内对角度不敏感，并且 RSD 值与流速之间存在近乎线性的关系。大鼠皮层的 RSD-OCT 测量表明，它可以量化血流速度并绘制体内血管网络图。