Summary: Lysosomes are the recycling centers of the cell where organelles and proteins are degraded during autophagy and macropinocytosis; they also serve as signaling hubs that control the activity of mTORC1. In this issue, Rebecca and colleagues report the development of a new type of lysosomal inhibitor for cancer therapy that can inhibit multiple lysosomal activities that are needed for tumor cell survival and growth. Cancer Discov; 7(11); 1218–20. ©2017 AACR.

See related article by Rebecca et al., p. 1266.

中文翻译：

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靶向溶酶体进行癌症治疗

简介：溶酶体是细胞的回收中心，自噬和巨胞饮过程中细胞器和蛋白质降解。它们还充当控制mTORC1活动的信号中枢。在本期杂志中，Rebecca及其同事报告了一种新型的溶酶体抑制剂，用于癌症治疗，可以抑制肿瘤细胞存活和生长所需的多种溶酶体活性。巨蟹座Discov; 7（11）；1218–20。©2017 AACR。

参见Rebecca等人的相关文章，第1页。1266。