Cannabinoid receptor type-1 (CB1) is known to have a substantial impact on the regulation of energy metabolism via central and peripheral mechanisms. In this issue of the JCI, Ruiz de Azua and colleagues provide important insights into the regulation of adipocyte physiology by CB1. Mice with adipocyte-specific deletion of the CB1-encoding gene had an overall improved metabolic profile in addition to reduced body weight and total adiposity. These changes were associated with an increase in sympathetic tone of the adipose tissue and expansion of activated macrophages, both of which occurred prior to changes in body weight, lending support to a causal relationship between loss of CB1 in adipocytes and systemic metabolic changes. This work identifies adipocyte CB1s as a potential novel peripheral target for affecting systemic metabolism with diminished CNS effects.

已知1类大麻受体（CB1）通过中枢和外周机制对能量代谢的调节具有实质性影响。在本期JCI中，Ruiz de Azua及其同事提供了有关CB1对脂肪细胞生理调节的重要见解。脂肪细胞特异性删除CB1编码基因的小鼠除体重减轻和总脂肪减少外，总体代谢状况也得到改善。这些变化与脂肪组织的交感神经张力增高和活化的巨噬细胞的扩张有关，这两者都发生在体重变化之前，这为脂肪细胞中CB1的丧失与全身代谢变化之间的因果关系提供了支持。