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Location, Location, Location: Spatio-Temporal Cues That Define the Cell of Origin in Melanoma.
Cell Stem Cell ( IF 19.8 ) Pub Date : 2017-Nov-02 , DOI: 10.1016/j.stem.2017.10.009
Maria S. Soengas , E. Elizabeth Patton

It is unclear whether melanoma initiates from mature melanocytes or stem cell precursors. In this issue of Cell Stem Cell, Moon et al. (2017) and Köhler et al. (2017) use in vivo lineage tracing to demonstrate that these two possibilities may occur downstream of the same pro-tumorigenic lesions, depending on environmental factors or the anatomical location.

中文翻译:

位置,位置,位置:定义黑色素瘤起源细胞的时空提示。

目前尚不清楚黑素瘤是从成熟的黑素细胞还是干细胞前体引发的。在本期的《细胞干细胞》中,Moon等人。(2017)和Köhler等人。(2017)使用体内谱系追踪来证明这两种可能性可能发生在同一促癌性病变的下游,具体取决于环境因素或解剖位置。
更新日期:2017-11-02
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