Simultaneous IR-Spectroscopic Observation of α-Synuclein, Lipids, and Solvent Reveals an Alternative Membrane-Induced Oligomerization Pathway,ChemBioChem

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Simultaneous IR-Spectroscopic Observation of α-Synuclein, Lipids, and Solvent Reveals an Alternative Membrane-Induced Oligomerization Pathway
ChemBioChem ( IF 2.6 ) Pub Date : 2017-11-02 02:35:53 , DOI: 10.1002/cbic.201700355
Mohammad A. Fallah ₁ , Hanne R. Gerding ₂ , Christian Scheibe ₁ , Malte Drescher ₁ , Christiaan Karreman ₂ , Stefan Schildknecht ₂ , Marcel Leist ₂ , Karin Hauser ₁

Affiliation

Aggregation of Parkinson's-associated proteins: The presence of a membrane changes the oligomerization pathway of Parkinson's-associated intrinsically disordered protein (IDP) α-synuclein from that observed in solution. Membrane remodeling and disruption are caused not by the final aggregates, but by specific membrane–aggregate interaction.

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