Microbial metabolites have attracted increasing interest as a source of therapeutics and as probes for biological mechanisms. New microbial metabolites and derivatives targeted at inflammation and bone disease therapy have been identified by focusing on prostaglandin release, osteoblast differentiation and immune cell functions. These modulators of inflammatory processes and bone disease contribute to our understanding of biological mechanisms and support identification of the therapeutic potential of drug lead candidates. The present review describes recent advances in the chemistry and analysis of inhibitors of prostaglandin release or other functional molecules of immune cells, as well as inducers of osteoblast differentiation, including biological and pharmacological activities.The Journal of Antibiotics advance online publication, 1 November 2017; doi:10.1038/ja.2017.138.

中文翻译：

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针对炎症和骨疾病治疗的微生物代谢物和衍生物：化学、生物活性和药理学。


微生物代谢物作为治疗学的来源和生物机制的探针引起了越来越多的兴趣。通过关注前列腺素释放、成骨细胞分化和免疫细胞功能，已经确定了针对炎症和骨疾病治疗的新微生物代谢物和衍生物。这些炎症过程和骨疾病的调节剂有助于我们了解生物机制，并支持识别先导候选药物的治疗潜力。本综述介绍了前列腺素释放抑制剂或免疫细胞其他功能分子以及成骨细胞分化诱导剂的化学和分析的最新进展，包括生物和药理活性。《抗生素杂志》高级在线出版，2017 年 11 月 1 日； doi：10.1038/ja.2017.138。