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Cellular uptake of modified aminoglycosides.
The Journal of Antibiotics ( IF 2.1 ) Pub Date : 2017-Nov-01 , DOI: 10.1038/ja.2017.131
Kaivin Hadidi 1 , Ezequiel Wexselblatt 1 , Jeffrey D Esko 2 , Yitzhak Tor 1
Affiliation  

The uptake of modified amino- and guanidino-glycosides derived from kanamycin, tobramycin and neomycin in native and mutant CHO cells is examined using confocal microscopy and flow cytometry, illustrating the significance of multivalency for mammalian cell internalization of carriers that specifically interact with cell surface heparan sulfate proteoglycans.The Journal of Antibiotics advance online publication, 1 November 2017; doi:10.1038/ja.2017.131.

中文翻译:


修饰氨基糖苷类的细胞摄取。



使用共聚焦显微镜和流式细胞术检查天然和突变 CHO 细胞中卡那霉素、妥布霉素和新霉素衍生的修饰氨基糖苷和胍基糖苷的摄取,说明多价性对于与细胞表面乙酰肝素特异性相互作用的载体的哺乳动物细胞内化的重要性硫酸盐蛋白聚糖。《抗生素杂志》高级在线出版,2017 年 11 月 1 日; doi:10.1038/ja.2017.131。
更新日期:2017-11-01
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