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Neural Architecture at the Cellular and Molecular Level
Neuron ( IF 14.7 ) Pub Date : 2017-11-01 00:00:00 , DOI: 10.1016/j.neuron.2017.10.018


The striking diversity of cells in the nervous system has long inspired scientists to ask how the various cell types of the nervous system are generated, wired, and respond to each other to allow for the diverse and dynamic behaviors generated by the brain. Neuronal cell biology has been a cornerstone of Neuron since its inception in 1988 and was the focus of a previous special issue in 2003. Just as systems and cognitive neuroscience is flourishing with new technologies to manipulate and visualize neural circuits, molecular and cellular neuroscience is in a time of growth and rapid discovery. Neuroscientists now have technologies at the ready that allow for the ability to detect, quantify, and disrupt cellular and molecular processes with unprecedented temporal and spatial precision. The goal of this special issue is to showcase to the neuroscience community the latest discoveries and ideas in neuronal cell biology and spotlight the importance of understanding the cellular and molecular underpinnings of nervous system architecture and function. In addition, we also want to capture the attention of “traditional” cell biologists (from outside of neuroscience) and inspire them to think about the unique challenges the nervous system presents for cell biology and perhaps even get them to deploy their talents and expertise in this direction. Much in the way that chemists, physicists, and theoreticians have galvanized neuroscience over the last decade, we see great potential for the field in bringing more cell biologists and cell biological approaches into the neuroscience fold.

中文翻译:


细胞和分子水平的神经结构

长期以来,神经系统中的细胞具有惊人的多样性,这激发了科学家们的疑问:神经系统的各种细胞类型是如何产生,连接和相互反应的,以允许大脑产生多种多样的动态行为。神经元细胞生物学一直是神经元的基石自1988年成立以来,它一直是2003年上一期特刊的重点。正如系统和认知神经科学通过操纵和可视化神经回路的新技术蓬勃发展一样,分子和细胞神经科学正处于发展迅速的时代。神经科学家现在拥有随时可用的技术,这些技术可以以前所未有的时间和空间精度检测,量化和破坏细胞和分子过程。本期特刊的目的是向神经科学界展示神经元细胞生物学的最新发现和思想,并着重了解理解神经系统结构和功能的细胞和分子基础的重要性。此外,我们还希望引起“传统”细胞生物学家的关注(来自神经科学以外的领域),并激发他们思考神经系统对细胞生物学提出的独特挑战,甚至可能使他们在此方向上发挥才能和专业知识。在过去的十年中,化学家,物理学家和理论家极大地推动了神经科学的发展,我们认为该领域具有巨大的潜力,可以将更多的细胞生物学家和细胞生物学方法引入神经科学领域。

更新日期:2017-11-01
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