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Regulation of mRNA Translation in Neurons-A Matter of Life and Death.
Neuron ( IF 14.7 ) Pub Date : 2017-Nov-01 , DOI: 10.1016/j.neuron.2017.09.057 Mridu Kapur 1 , Caitlin E Monaghan 1 , Susan L Ackerman 1
Neuron ( IF 14.7 ) Pub Date : 2017-Nov-01 , DOI: 10.1016/j.neuron.2017.09.057 Mridu Kapur 1 , Caitlin E Monaghan 1 , Susan L Ackerman 1
Affiliation
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Dynamic regulation of mRNA translation initiation and elongation is essential for the survival and function of neural cells. Global reductions in translation initiation resulting from mutations in the translational machinery or inappropriate activation of the integrated stress response may contribute to pathogenesis in a subset of neurodegenerative disorders. Aberrant proteins generated by non-canonical translation initiation may be a factor in the neuron death observed in the nucleotide repeat expansion diseases. Dysfunction of central components of the elongation machinery, such as the tRNAs and their associated enzymes, can cause translational infidelity and ribosome stalling, resulting in neurodegeneration. Taken together, dysregulation of mRNA translation is emerging as a unifying mechanism underlying the pathogenesis of many neurodegenerative disorders.
中文翻译：
神经元中 mRNA 翻译的调控——生死攸关的大事。
mRNA翻译起始和延伸的动态调节对于神经细胞的存活和功能至关重要。由于翻译机制的突变或综合应激反应的不适当激活导致翻译起始的整体减少可能有助于神经退行性疾病子集的发病机制。由非规范翻译起始产生的异常蛋白质可能是在核苷酸重复扩增疾病中观察到的神经元死亡的一个因素。延伸机制的中心成分（例如 tRNA 及其相关酶）的功能障碍可导致翻译不忠和核糖体停滞，从而导致神经变性。综合起来，
更新日期：2017-11-01
中文翻译：
神经元中 mRNA 翻译的调控——生死攸关的大事。
mRNA翻译起始和延伸的动态调节对于神经细胞的存活和功能至关重要。由于翻译机制的突变或综合应激反应的不适当激活导致翻译起始的整体减少可能有助于神经退行性疾病子集的发病机制。由非规范翻译起始产生的异常蛋白质可能是在核苷酸重复扩增疾病中观察到的神经元死亡的一个因素。延伸机制的中心成分（例如 tRNA 及其相关酶）的功能障碍可导致翻译不忠和核糖体停滞，从而导致神经变性。综合起来，
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