We investigated whether motion correction of gated ¹⁸F-fluoride PET/CT and PET/MRI of the aortic valve could improve PET quantitation and image quality. Methods: A diffeomorphic, mass-preserving, anatomy-guided registration algorithm was used to align the PET images from 4 cardiac gates, preserving all counts, and apply them to the PET/MRI and PET/CT data of 6 patients with aortic stenosis. Measured signal-to-noise ratios (SNRs) and target-to-background ratios (TBRs) were compared with the standard method of using only the diastolic gate. Results: High-intensity aortic valve ¹⁸F-fluoride uptake was observed in all patients. After motion correction, SNR and TBR increased compared with the median diastolic gate (SNR, 51.61 vs. 21.0; TBR, 2.85 vs. 2.22) and the median summed data (SNR, 51.61 vs. 34.10; TBR, 2.85 vs. 1.95) (P = 0.028 for all). Furthermore, noise decreased from 0.105 (median, diastolic) to 0.042 (median, motion-corrected) (P = 0.028). Conclusion: Motion correction of hybrid ¹⁸F-fluoride PET markedly improves SNR, resulting in improved image quality.

我们研究了门控¹⁸ F氟化物PET / CT和主动脉瓣PET / MRI的运动校正是否可以改善PET定量和图像质量。方法：采用变形，质量保留，解剖学指导的配准算法，对来自4个心脏门的PET图像进行对齐，保留所有计数，并将其应用于6例主动脉瓣狭窄患者的PET / MRI和PET / CT数据。将测得的信噪比（SNR）和目标背景比（TBR）与仅使用舒张门的标准方法进行了比较。结果：高强度主动脉瓣膜¹⁸在所有患者中均观察到氟吸收。经过运动校正后，SNR和TBR与舒张门中位数（SNR，51.61 vs. 21.0; TBR，2.85 vs.2.22）和中位数求和数据（SNR，51.61 vs. 34.10; TBR，2.85 vs 1.95）相比有所增加（对于所有P = 0.028）。此外，噪声从0.105（中位数，舒张期）降低到0.042（中位数，经运动校正）（P = 0.028）。结论：混合¹⁸ F-氟化物PET的运动校正显着提高了SNR，从而提高了图像质量。