Mixtures of polymer (chondroitin sulfate) and monomer (AMPS) in the presence of co-monomer (MBA) were employed for the production of hydrogels, with adjustable properties, following free radical copolymerization. The hydrogel’s structural properties were assessed by FTIR, DSC, TGA, SEM and XRD which confirmed the development and stability of synthesized structure. The results from FTIR analysis showed that CS react with the AMPS monomer during the polymerization process and confirmed the grafting of AMPS chains onto CS backbone. The surface morphology of CS-co-poly(AMPS) hydrogels, as evident by SEM, corresponds to their improved swelling ability due to high porosity. Thermal analysis showed that crosslinking formed a stable hydrogel network which is thermally more stable than its basic ingredients. The effects of pH revealed an increasing trend in swelling with increasing concentration of either CS or AMPS. In addition, different modalities for drug loading were studied with respect to drug homogeneous distribution; loxoprofen sodium was employed as model drug and was loaded by swelling-diffusion method. In vitro drug release profiles and kinetics were assessed to confirm their reproducibility and reliability. Higuchi model is the best fit model to explain drug release from formed gels indicating diffusion-controlled release. Similarly, Korsmeyer–Peppas model yields remarkably good adjustments where release kinetics involves a combination of diffusion in hydrated matrix and polymer relaxation. Conclusively, CS-co-poly(AMPS) hydrogels could be a potential alternate to conventional dosage forms for controlled delivery of loxoprofen sodium for extended period of time.

在自由基共聚之后，在共聚单体（MBA）存在下，将聚合物（硫酸软骨素）和单体（AMPS）的混合物用于生产具有可调节性能的水凝胶。通过FTIR，DSC，TGA，SEM和XRD对水凝胶的结构性能进行了评估，证实了合成结构的发展和稳定性。FTIR分析的结果表明，CS在聚合过程中与AMPS单体反应，并证实了AMPS链接枝到CS骨架上。如通过SEM所见，CS-共聚（AMPS）水凝胶的表面形态对应于其由于高孔隙率而改善的溶胀能力。热分析表明，交联形成了稳定的水凝胶网络，该网络比其基本成分具有更高的热稳定性。pH的影响表明，随着CS或AMPS浓度的增加，溶胀趋势也增加。此外，关于药物均质分布，研究了不同的载药方式。洛索洛芬钠用作模型药物，并通过溶胀-扩散法加载。一世评估了体外药物释放曲线和动力学，以确认其可重复性和可靠性。Higuchi模型是最合适的模型，可以解释药物从形成的凝胶中释放，表明扩散控制释放。同样，Korsmeyer-Peppas模型产生了非常好的调整，其中释放动力学涉及在水合基质中扩散和聚合物松弛的组合。最后，CS-co-poly（AMPS）水凝胶可能是常规剂型的替代品，可用于长时间控制洛索洛芬钠的控制释放。