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What is precise pathophysiology in development of hypertension in pregnancy? Precision medicine requires precise physiology and pathophysiology
Drug Discovery Today ( IF 6.5 ) Pub Date : 2017-10-31 , DOI: 10.1016/j.drudis.2017.10.021
Qinqin Gao , Jiaqi Tang , Na Li , Bailin Liu , Mengshu Zhang , Miao Sun , Zhice Xu

It is widely accepted that placental ischemia is central in the evolution of hypertension in pregnancy. Many studies and reviews have targeted placental ischemia to explain mechanisms for initiating pregnancy hypertension. The placenta is rich in blood vessels, which are the basis for developing placental ischemia. However, is the physiology of placental vessels the same as that of nonplacental vessels? What is the pathophysiology of placental vessels in development of pregnancy hypertension? This review aims to provide a comprehensive summary of special features of placental vascular regulations and the pathophysiological changes linked to preeclamptic conditions. Interestingly, some popular theories or accepted concepts could be based on our limited knowledge and evidence regarding placental vascular physiology, pharmacology and pathophysiology. New views raised could offer interesting ideas for future investigation of mechanisms as well as targets for pregnancy hypertension.



中文翻译:

妊娠高血压病的确切病理生理是什么?精密医学需要精确的生理学和病理生理学

胎盘局部缺血是妊娠高血压病发展的中心,这一点已被广泛接受。许多研究和评论都针对胎盘缺血来解释引发妊娠高血压的机制。胎盘富含血管,这是发展胎盘缺血的基础。但是,胎盘血管的生理与非胎盘血管的生理相同吗?妊娠高血压发展过程中胎盘血管的病理生理学是什么?这篇综述旨在提供胎盘血管调节的特殊特征以及与先兆子痫病有关的病理生理变化的全面总结。有趣的是,一些流行的理论或公认的概念可能基于我们对胎盘血管生理学,药理学和病理生理学的有限​​知识和证据。

更新日期:2017-10-31
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