Zebrafish, an amenable small teleost fish with a complex mammal-like circulatory system, is being increasingly used for drug screening and toxicity studies. It combines the biological complexity of in vivo models with a higher-throughput screening capability compared with other available animal models. Externally growing, transparent embryos, displaying well-defined blood and lymphatic vessels, allow the inexpensive, rapid, and automatable evaluation of drug candidates that are able to inhibit neovascularisation. Here, we briefly review zebrafish as a model for the screening of anti(lymph)angiogenic drugs, with emphasis on the advantages and limitations of the different zebrafish-based in vivo assays.

斑马鱼是一种易于驯服的小型硬骨鱼，具有复杂的哺乳动物样循环系统，正在越来越多地用于药物筛选和毒性研究。与其他可用的动物模型相比，它结合了体内模型的生物学复杂性和更高通量的筛选能力。外部生长的透明胚胎显示出明确的血液和淋巴管，可以对能够抑制新血管形成的候选药物进行廉价，快速和自动化的评估。在这里，我们简要回顾斑马鱼作为筛选抗（淋巴）血管生成药物的模型，重点介绍基于斑马鱼的体内实验的优势和局限性。