Cysteine cathepsins are a group of proteases involved in many physiological and pathological processes. Yet, the selective detection and inhibition of individual cathepsins is still challenging. This editorial is discussing the context of a recent work introducing a designed ankyrin repeat protein (DARPin) as novel approach for selective targeting of the protease cathepsin B.

中文翻译：

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块上的新孩子

半胱氨酸组织蛋白酶是涉及许多生理和病理过程的一组蛋白酶。然而，选择性检测和抑制单个组织蛋白酶仍具有挑战性。这篇社论讨论了最近工作的背景，该工作介绍了设计的锚蛋白重复蛋白（DARPin），作为选择性靶向蛋白酶组织蛋白酶B的新方法。