Cardiac Metabolic Deregulation Induced by the Tyrosine Kinase Receptor Inhibitor Sunitinib is rescued by Endothelin Receptor Antagonism,Theranostics

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Cardiac Metabolic Deregulation Induced by the Tyrosine Kinase Receptor Inhibitor Sunitinib is rescued by Endothelin Receptor Antagonism
Theranostics ( IF 12.4 ) Pub Date : 2017-07-08 , DOI: 10.7150/thno.19551
Joevin Sourdon ₁ , Franck Lager ₂ , Thomas Viel ₁ , Daniel Balvay ₁ , Rebecca Moorhouse ₃ , Evangeline Bennana _{2,

4} , Gilles Renault ₂ , Pierre-Louis Tharaux ₁ , Neeraj Dhaun ₅ , Bertrand Tavitian _{1,

6}

Affiliation

The growing field of cardio-oncology addresses the side effects of cancer treatment on the cardiovascular system. Here, we explored the cardiotoxicity of the antiangiogenic therapy, sunitinib, in the mouse heart from a diagnostic and therapeutic perspective.

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