The nuclear receptor family of transcription factor proteins mediates endocrine function and plays critical roles in the development, physiology and pharmacology. Malfunctioning nuclear receptors are associated with several disease states. The functional activity of nuclear receptors is regulated by small molecular hormonal and synthetic molecules. Multiple sources of evidence have identified and distinguished between the different allosteric pathways initiated by ligands, DNA and cofactors such as co-activators and co-repressors. Also, these biophysical studies are attempting to determine how these pathways that regulate co-activator and DNA recognition can control gene transcription. Thus, there is a growing interest in determining the genome-scale impact of allostery in nuclear receptors. Today, it is accepted that a detailed understanding of the allosteric regulatory pathways within the nuclear receptor molecular complex will enable the development of efficient drug therapies in the long term.

转录因子蛋白的核受体家族介导内分泌功能，并在发育、生理学和药理学中发挥关键作用。核受体功能障碍与多种疾病状态有关。核受体的功能活性由小分子激素和合成分子调节。多种证据来源已鉴定并区分了由配体、DNA 和辅因子（例如辅激活因子和辅抑制因子）引发的不同变构途径。此外，这些生物物理学研究正试图确定这些调节共激活剂和 DNA 识别的途径如何控制基因转录。因此，人们对确定核受体变构对基因组规模的影响越来越感兴趣。如今，人们普遍认为，对核受体分子复合物内变构调节途径的详细了解将有助于开发长期有效的药物疗法。