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Synthesis and Characterization of Plug-and-Play Polyurethane Urea Elastomers as Biodegradable Matrixes for Tissue Engineering Applications
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2017-11-01 00:00:00 , DOI: 10.1021/acsbiomaterials.7b00512 Alysha P. Kishan 1 , Thomas Wilems 2 , Sahar Mohiuddin 1 , Elizabeth M. Cosgriff-Hernandez 2
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2017-11-01 00:00:00 , DOI: 10.1021/acsbiomaterials.7b00512 Alysha P. Kishan 1 , Thomas Wilems 2 , Sahar Mohiuddin 1 , Elizabeth M. Cosgriff-Hernandez 2
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The highly tunable mechanical properties and resilience of polyurethanes make them promising candidates for tissue engineering applications. Biodegradability is conferred by incorporation of hydrolytically or enzymatically cleavable moieties into the polyurethane structure. A common choice for the biodegradable soft segment is a poly(ether ester) triblock copolymer synthesized by ring opening polymerization of the polyester from a polyether macroinitiator. Herein, we describe a new “plug-and-play” approach for triblock synthesis based on urethane block coupling that enables finer control of block lengths and ease of segmental tuning. The inclusion of urethane linkages in the soft segment was also hypothesized to promote hydrogen bonding between the segments with an associated increase in modulus, tensile strength, and ultimate elongation. Hard segment content of the biodegradable polyurethane urea was varied to demonstrate the tunable tensile properties and degradation rate. As expected, increasing hard segment content led to large increases in initial secant modulus and tensile strength. A corollary decrease in ultimate elongation, elastic recovery, and degradation rate was also observed with increasing hard segment content. Finally, cytocompatibility and hydrolytic degradation of electrospun polyurethane meshes were evaluated to establish the potential use of these biodegradable matrixes as tissue engineering scaffolds. All of the polyurethane formulations displayed comparable cytocompatibilty to tissue culture plastic controls and hydrolytic chain scission of the polyester soft segment. Overall, this synthetic approach provides a platform to produce biodegradable polyurethane ureas with enhanced control over segmental chemistry, mechanical properties, and degradation rate.
中文翻译：
即插即用型聚氨酯尿素弹性体的合成与表征，作为组织工程应用中的可生物降解基质
聚氨酯的高度可调节的机械性能和回弹力使其成为有希望的组织工程应用候选材料。通过将可水解或酶促可裂解的部分结合到聚氨酯结构中来赋予生物可降解性。可生物降解的软链段的通常选择是通过聚酯从聚醚大分子引发剂的开环聚合反应而合成的聚（醚酯）三嵌段共聚物。本文中，我们描述了一种基于氨基甲酸酯嵌段偶联的三嵌段合成的新“即插即用”方法，该方法能够更好地控制嵌段长度，并易于进行片段调节。还假设在软链段中包含氨基甲酸酯键，以促进链段之间的氢键结合，从而增加模量，拉伸强度和极限伸长率。改变生物可降解聚氨酯脲的硬链段含量，以证明可调节的拉伸性能和降解速率。不出所料，硬链段含量的增加导致初始正割模量和抗张强度大大提高。随着硬链段含量的增加，最终伸长率，弹性回复率和降解率也随之降低。最后，对电纺聚氨酯网的细胞相容性和水解降解进行了评估，以确立这些可生物降解基质作为组织工程支架的潜在用途。所有聚氨酯配方均表现出与组织培养塑料对照和聚酯软链段的水解断链相当的细胞相容性。全面的，
更新日期：2017-11-01
中文翻译：
即插即用型聚氨酯尿素弹性体的合成与表征，作为组织工程应用中的可生物降解基质
聚氨酯的高度可调节的机械性能和回弹力使其成为有希望的组织工程应用候选材料。通过将可水解或酶促可裂解的部分结合到聚氨酯结构中来赋予生物可降解性。可生物降解的软链段的通常选择是通过聚酯从聚醚大分子引发剂的开环聚合反应而合成的聚（醚酯）三嵌段共聚物。本文中，我们描述了一种基于氨基甲酸酯嵌段偶联的三嵌段合成的新“即插即用”方法，该方法能够更好地控制嵌段长度，并易于进行片段调节。还假设在软链段中包含氨基甲酸酯键，以促进链段之间的氢键结合，从而增加模量，拉伸强度和极限伸长率。改变生物可降解聚氨酯脲的硬链段含量，以证明可调节的拉伸性能和降解速率。不出所料，硬链段含量的增加导致初始正割模量和抗张强度大大提高。随着硬链段含量的增加，最终伸长率，弹性回复率和降解率也随之降低。最后，对电纺聚氨酯网的细胞相容性和水解降解进行了评估，以确立这些可生物降解基质作为组织工程支架的潜在用途。所有聚氨酯配方均表现出与组织培养塑料对照和聚酯软链段的水解断链相当的细胞相容性。全面的，
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