A Polypropylene-Integrated Bilayer Composite Mesh with Bactericidal and Antiadhesive Efficiency for Hernia Operations,ACS Biomaterials Science & Engineering

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A Polypropylene-Integrated Bilayer Composite Mesh with Bactericidal and Antiadhesive Efficiency for Hernia Operations
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2017-11-01 00:00:00 , DOI: 10.1021/acsbiomaterials.7b00757
Umran Aydemir Sezer , Vildan Sanko , Mehmet Gulmez , Elif Sayman , Basak Aru ₁ , Zehra Nur Yuksekdag ₂ , Ali Aktekin , Fugen Vardar Aker , Serdar Sezer

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Polypropylene (PP) mesh has been widely used in hernia fixation operations for more than one hundred years, and peritoneal adhesion is still one of the main complications after hernia fixation operations. For preventing peritoneal adhesion, many solutions have been offered, including gel systems, adhesion barrier membranes, and bilayer meshes. Among these, bilayer meshes come to the forefront as they serve for both hernia repair and adhesion prevention. In this study, we developed an easy and effective method to produce a multifunctional PP-integrated bilayer mesh composed of poly(lactic-co-glycolic acid) and chitosan with no need for neutralization. We made the composite mesh by electrospinning a layer onto the PP mesh. We evaluated the material characteristics, in vitro bactericidal activities, and interactions between the cells and materials. Then, we conducted in vivo efficiency studies. The results proved that the PP-integrated bilayer composite mesh is bactericidal against Escherichia coli and Staphylococcus aureus, is tissue-compatible, and supremely prevents adhesion.

中文翻译：

一种用于疝气手术的具有杀菌和抗粘附效率的聚丙烯集成双层复合网

聚丙烯网已在疝气固定手术中被广泛使用一百多年，腹膜粘连仍然是疝气固定手术后的主要并发症之一。为了防止腹膜粘连，已经提供了许多解决方案，包括凝胶系统，粘连屏障膜和双层网。在这些当中，双层网片最重要的是它们既可以修复疝气，又可以防止粘连。在这项研究中，我们开发了一种简单而有效的方法，以产生多功能PP-集成双层网状由聚（乳酸-共-乙醇酸）和壳聚糖，无需中和。我们通过将一层静电纺到PP网格上来制作复合网格。我们评估了材料特性，体外杀菌活性以及细胞与材料之间的相互作用。然后，我们进行了体内效率研究。结果证明，PP-集成双层复合网对大肠杆菌和金黄色葡萄球菌具有杀菌作用，具有组织相容性，并最大程度地防止了粘附。

更新日期：2017-11-01

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