Synthesis and optical properties of cyanine dyes with an aromatic azonia skeleton,Organic Chemistry Frontiers

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Synthesis and optical properties of cyanine dyes with an aromatic azonia skeleton
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2017-10-20 00:00:00 , DOI: 10.1039/c7qo00889a
Xin-Long Sha _{1,

2,

3,

4,

5} , Jin-Yun Niu _{3,

4,

5,

6,

7} , Ru Sun _{1,

2,

3,

4,

5} , Yu-Jie Xu _{3,

4,

5,

6,

7} , Jian-Feng Ge _{1,

2,

3,

4,

5}

Affiliation

Six cyanine dyes with an aromatic azonia skeleton (1a–f) were obtained by the reaction of chlorinated heptamethylene cyanine and 2-aminopyridine derivatives. Five of them (1a–d and 1f) emit red and near-infrared fluorescence at 600–800 nm. The fluorescent stains of living cells indicate that they can penetrate the cell membrane, especially the hydroxyl-substituted dye (1c), it has lysosome targeting ability.

中文翻译：

芳族氮杂骨架花菁染料的合成及光学性质

通过氯化七亚甲基花青与2-氨基吡啶衍生物的反应，获得了六种具有芳族氮杂骨架（1a–f）的花青染料。其中五个（1a–d和1f）在600–800 nm处发出红色和近红外荧光。活细胞的荧光染色表明它们可以穿透细胞膜，尤其是羟基取代的染料（1c），它具有溶酶体靶向能力。

更新日期：2017-11-01

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