当前位置：
X-MOL 学术
›
Chem. Sci.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Achieving efficient photodynamic therapy under both normoxia and hypoxia using cyclometalated Ru(ii) photosensitizer through type I photochemical process†
Chemical Science ( IF 7.6 ) Pub Date : 2017-10-31 00:00:00 , DOI: 10.1039/c7sc03765a Zhuang Lv 1 , Huanjie Wei 1 , Qing Li 2 , Xianlong Su 2 , Shujuan Liu 1 , Kenneth Yin Zhang 1 , Wen Lv 1 , Qiang Zhao 1 , Xianghong Li 2 , Wei Huang 1, 3
Chemical Science ( IF 7.6 ) Pub Date : 2017-10-31 00:00:00 , DOI: 10.1039/c7sc03765a Zhuang Lv 1 , Huanjie Wei 1 , Qing Li 2 , Xianlong Su 2 , Shujuan Liu 1 , Kenneth Yin Zhang 1 , Wen Lv 1 , Qiang Zhao 1 , Xianghong Li 2 , Wei Huang 1, 3
Affiliation
|
Photodynamic therapy (PDT) through the generation of singlet oxygen utilizing photosensitizers (PSs) is significantly limited under hypoxic conditions in solid tumors. So it is meaningful to develop effective PSs which can maintain excellent therapeutic effects under hypoxia. Here we reported a coumarin-modified cyclometalated Ru(II) photosensitizer (Ru2), which exhibits lower oxidation potential and stronger absorption in the visible region than the coumarin-free counterpart. The evaluation of the PDT effect was performed under both normoxia and hypoxia. The results showed that Ru2 has a better therapeutic effect than the coumarin-free counterpart in in vitro experiments. Especially under hypoxia, Ru2 still retained an excellent PDT effect, which can be attributed to the direct charge transfer between the excited PS and an adjacent substrate through a type I photochemical process, forming highly-oxidative hydroxyl radicals to damage tumor cells. The anti-tumor activity of Ru2 was further proven to be effective in tumor-bearing mice, and tumor growth was inhibited remarkably under PDT treatment.
中文翻译：
使用环金属化 Ru(ii) 光敏剂通过 I 型光化学过程在常氧和缺氧下实现有效的光动力治疗†
在实体瘤的缺氧条件下，通过利用光敏剂（PS）产生单线态氧的光动力疗法（PDT）受到显着限制。因此开发有效的PSs并在缺氧条件下仍能保持良好的治疗效果具有重要意义。在这里，我们报道了一种香豆素修饰的环金属化Ru（II）光敏剂（Ru2），与不含香豆素的对应物相比，它在可见光区域表现出更低的氧化电位和更强的吸收。在常氧和缺氧条件下进行PDT效果评价。结果表明，体外实验中Ru2比不含香豆素的对应物具有更好的治疗效果。尤其是在缺氧条件下，Ru2仍然保留了优异的PDT效果，这可以归因于激发的PS与相邻底物之间通过I型光化学过程直接进行电荷转移，形成高氧化性羟基自由基来损伤肿瘤细胞。Ru2的抗肿瘤活性进一步被证明对荷瘤小鼠有效，PDT治疗下肿瘤生长受到显着抑制。
更新日期：2017-10-31
中文翻译：
使用环金属化 Ru(ii) 光敏剂通过 I 型光化学过程在常氧和缺氧下实现有效的光动力治疗†
在实体瘤的缺氧条件下，通过利用光敏剂（PS）产生单线态氧的光动力疗法（PDT）受到显着限制。因此开发有效的PSs并在缺氧条件下仍能保持良好的治疗效果具有重要意义。在这里，我们报道了一种香豆素修饰的环金属化Ru（II）光敏剂（Ru2），与不含香豆素的对应物相比，它在可见光区域表现出更低的氧化电位和更强的吸收。在常氧和缺氧条件下进行PDT效果评价。结果表明，体外实验中Ru2比不含香豆素的对应物具有更好的治疗效果。尤其是在缺氧条件下，Ru2仍然保留了优异的PDT效果，这可以归因于激发的PS与相邻底物之间通过I型光化学过程直接进行电荷转移，形成高氧化性羟基自由基来损伤肿瘤细胞。Ru2的抗肿瘤活性进一步被证明对荷瘤小鼠有效，PDT治疗下肿瘤生长受到显着抑制。
京公网安备 11010802027423号