Capturing Circulating Tumor Cells through a Combination of Hierarchical Nanotopography and Surface Chemistry,ACS Biomaterials Science & Engineering

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Capturing Circulating Tumor Cells through a Combination of Hierarchical Nanotopography and Surface Chemistry
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2017-10-31 00:00:00 , DOI: 10.1021/acsbiomaterials.7b00683
Guang Yang _{1,

2} , Xilin Li ₁ , Yang He ₁ , Xiang Xiong ₁ , Pu Wang ₁ , Shaobing Zhou ₁

Affiliation

Circulating tumor cells (CTCs) have become known as minimally invasive multifunctional biomarkers for earlier diagnosis, prognosis, recurrence risk assessment, and therapeutic monitoring in recent years. However, effectively capturing these CTCs is still difficult because of the extremely low abundance of CTCs and the diverse phenotypes of cancer cells. In this study, we present a novel necklace-like polydopamine nanosphere (PDA NS)/alginate composite nanofiber with a hierarchical nanotopographical structure and a surface chemical signal for capturing the CTCs. The height of the nanotopography, which is formed by connecting PDA NSs with nanofibers via electrospinning, can be easily adjusted by changing the size of the PDA NSs. Four types of cancer cells are employed to investigate the capture efficiency of the fiber. More importantly, in a blood environment containing rare cancer cells, the fiber still has a great ability to capture these cells. Therefore, this nanofiber is identified as a potential device for the diagnosis of cancer.

中文翻译：

通过分层纳米地形学和表面化学的结合捕获循环肿瘤细胞

近年来，循环肿瘤细胞（CTC）已成为用于早期诊断，预后，复发风险评估和治疗监测的微创多功能生物标志物。但是，由于CTC的丰度极低且癌细胞具有多种表型，因此有效捕获这些CTC仍然很困难。在这项研究中，我们提出了一种新颖的项链状聚多巴胺纳米球（PDA NS）/藻酸盐复合纳米纤维，具有分层的纳米形貌结构和用于捕获四氯化碳的表面化学信号。纳米形貌的高度是通过改变PDA NSs的尺寸来容易地调节的，该高度是通过静电纺丝将PDA NSs与纳米纤维连接在一起而形成的。四种类型的癌细胞用于研究纤维的捕获效率。更重要的是，在含有稀有癌细胞的血液环境中，纤维仍具有捕获这些细胞的强大能力。因此，这种纳米纤维被认为是诊断癌症的潜在设备。

更新日期：2017-10-31

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