An eco-friendly type III deep eutectic solvent (reline: choline chloride/urea) was used for the supplemental activator and reducing agent atom transfer radical polymerization (SARA ATRP) of different biorelevant hydrophilic monomers (HEA: 2-hydroxyethyl acrylate, HEMA: 2-hydroxyethyl methacrylate and AMPTMA: (3-acrylamidopropyl)trimethylammonium chloride) near room temperature (30 °C). The polymerization of HEA mediated by a safe and inexpensive SARA agent (Na₂S₂O₄) revealed controlled features, with polymers exhibiting low dispersity (Đ ≈ 1.3) throughout the course of the polymerization. Results also showed that typically, a slow and continuous feeding of the SARA agent to the reaction mixture afforded PHEA-Br with higher chain-end functionality and lower dispersity (Đ ≈ 1.1), in comparison to the one obtained without Na₂S₂O₄ feeding. As proof-of-concept, purified PHEA-Br macroinitiators were used for the preparation of different well-defined block copolymers (PHEA-b-PAMPTMA and PHEA-b-PMA).

使用环保型III型深共熔溶剂（线：氯化胆碱/尿素）作为不同生物相关亲水性单体（HEA：丙烯酸2-羟乙酯，HEMA：2）的辅助活化剂和还原剂原子转移自由基聚合（SARA ATRP）。甲基丙烯酸-羟乙酯和AMPTMA：（3-丙烯酰胺基丙基）三甲基氯化铵）接近室温（30°C）。由安全和廉价的SARA试剂（Na ₂ S ₂ O ₄）介导的HEA的聚合反应显示出受控的特征，聚合物的分散性低（Đ ≈1.3）。结果还表明，与 不使用Na ₂ S ₂ O相比，通常缓慢，连续地将SARA试剂进料到反应混合物中，可以使PHEA-Br具有更高的链端官能度和更低的分散度（Đ≈1.1）。₄喂食。作为概念验证，纯化的PHEA-Br大分子引发剂用于制备不同的定义明确的嵌段共聚物（PHEA- b- PAMPTMA和PHEA- b- PMA）。