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Ghrelin as a Survival Hormone
Trends in Endocrinology & Metabolism ( IF 11.4 ) Pub Date : 2017-12-01 , DOI: 10.1016/j.tem.2017.10.001 Bharath K Mani 1 , Jeffrey M Zigman 1
Trends in Endocrinology & Metabolism ( IF 11.4 ) Pub Date : 2017-12-01 , DOI: 10.1016/j.tem.2017.10.001 Bharath K Mani 1 , Jeffrey M Zigman 1
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Ghrelin administration induces food intake and body weight gain. Based on these actions, the ghrelin system was initially proposed as an antiobesity target. Subsequent studies using genetic mouse models have raised doubts about the role of the endogenous ghrelin system in mediating body weight homeostasis or obesity. However, this is not to say that the endogenous ghrelin system is not important metabolically or otherwise. Here we review an emerging concept in which the endogenous ghrelin system serves an essential function during extreme nutritional and psychological challenges to defend blood glucose, protect body weight, avoid exaggerated depression, and ultimately allow survival.
中文翻译：
胃饥饿素作为一种生存激素
施用胃饥饿素会诱导食物摄入和体重增加。基于这些作用，生长素释放肽系统最初被提议作为抗肥胖目标。随后使用遗传小鼠模型的研究对内源性生长素释放肽系统在调节体重稳态或肥胖中的作用提出了质疑。然而，这并不是说内源性生长素释放肽系统在代谢或其他方面不重要。在这里，我们回顾了一个新兴概念，其中内源性生长素释放肽系统在极端的营养和心理挑战中发挥着重要作用，以保护血糖、保护体重、避免过度抑郁并最终实现生存。
更新日期：2017-12-01
中文翻译：
胃饥饿素作为一种生存激素
施用胃饥饿素会诱导食物摄入和体重增加。基于这些作用，生长素释放肽系统最初被提议作为抗肥胖目标。随后使用遗传小鼠模型的研究对内源性生长素释放肽系统在调节体重稳态或肥胖中的作用提出了质疑。然而，这并不是说内源性生长素释放肽系统在代谢或其他方面不重要。在这里，我们回顾了一个新兴概念，其中内源性生长素释放肽系统在极端的营养和心理挑战中发挥着重要作用，以保护血糖、保护体重、避免过度抑郁并最终实现生存。
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