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Front Cover: Photo‐Triggered Fluorometric Hydrophobic Benzyl Alcohol for Soluble Tag‐Assisted Liquid‐Phase Peptide Synthesis (Asian J. Org. Chem. 11/2017)
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2017-10-30 , DOI: 10.1002/ajoc.201700528
Hiroki Wakamatsu 1 , Yohei Okada 2 , Masae Sugai 1 , Syed R. Hussaini 3 , Kazuhiro Chiba 1
Affiliation  

The Front Cover shows a schematic illustration of a tag‐assisted liquid phase peptide synthesis. This methodology employs a 2,5‐substituted hydrophobic benzyl alcohol as a soluble tag, which enables their fluorometric detection. Tagged peptides are not emissive, whereas blue fluorescence is observed by a photo‐triggered tag cleavage. Peptides are now recognized as promising therapeutic candidates, which are represented as drug capsules in the cover picture. Angiotensin III selective antagonist peptide was synthesized as a model. More information can be found in the Communication by Kazuhiro Chiba et al. on page 1584 in Issue 11, 2017 (DOI: 10.1002/ajoc.201700401).
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中文翻译:

前封面:用于引发标签辅助液相肽合成的光引发的疏水性疏水苄基醇(Asian J. Org。Chem。11/2017)

封面显示了标签辅助液相肽合成的示意图。该方法采用2,5-取代的疏水苄醇作为可溶性标签,从而可以进行荧光检测。标记的肽不发光,而通过光触发的标记裂解可观察到蓝色荧光。肽现在被认为是有前途的治疗候选物,在封面图片中以药物胶囊的形式表示。合成血管紧张素III选择性拮抗剂肽作为模型。可以在千叶一广等人的《交流》中找到更多信息。就在第11期,2017年1584页(:10.1002 / ajoc.201700401 DOI)。
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更新日期:2017-10-30
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