Front Cover: Photo‐Triggered Fluorometric Hydrophobic Benzyl Alcohol for Soluble Tag‐Assisted Liquid‐Phase Peptide Synthesis (Asian J. Org. Chem. 11/2017),Asian Journal of Organic Chemistry

当前位置： X-MOL 学术 › Asian J. Org. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Front Cover: Photo‐Triggered Fluorometric Hydrophobic Benzyl Alcohol for Soluble Tag‐Assisted Liquid‐Phase Peptide Synthesis (Asian J. Org. Chem. 11/2017)
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2017-10-30 , DOI: 10.1002/ajoc.201700528
Hiroki Wakamatsu ₁ , Yohei Okada ₂ , Masae Sugai ₁ , Syed R. Hussaini ₃ , Kazuhiro Chiba ₁

Affiliation

The Front Cover shows a schematic illustration of a tag‐assisted liquid phase peptide synthesis. This methodology employs a 2,5‐substituted hydrophobic benzyl alcohol as a soluble tag, which enables their fluorometric detection. Tagged peptides are not emissive, whereas blue fluorescence is observed by a photo‐triggered tag cleavage. Peptides are now recognized as promising therapeutic candidates, which are represented as drug capsules in the cover picture. Angiotensin III selective antagonist peptide was synthesized as a model. More information can be found in the Communication by Kazuhiro Chiba et al. on page 1584 in Issue 11, 2017 (DOI: 10.1002/ajoc.201700401).

中文翻译：

前封面：用于引发标签辅助液相肽合成的光引发的疏水性疏水苄基醇（Asian J. Org。Chem。11/2017）

封面显示了标签辅助液相肽合成的示意图。该方法采用2,5-取代的疏水苄醇作为可溶性标签，从而可以进行荧光检测。标记的肽不发光，而通过光触发的标记裂解可观察到蓝色荧光。肽现在被认为是有前途的治疗候选物，在封面图片中以药物胶囊的形式表示。合成血管紧张素III选择性拮抗剂肽作为模型。可以在千叶一广等人的《交流》中找到更多信息。就在第11期，2017年1584页（：10.1002 / ajoc.201700401 DOI）。

更新日期：2017-10-30

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11