Photo-induced DNA cleavage by zinc-substituted myoglobin with a redesigned active center,Inorganic Chemistry Frontiers

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Photo-induced DNA cleavage by zinc-substituted myoglobin with a redesigned active center
Inorganic Chemistry Frontiers ( IF 6.1 ) Pub Date : 2017-10-11 00:00:00 , DOI: 10.1039/c7qi00384f
Zhen-Hua Shi _{1,

2,

3,

4} , Ke-Jie Du _{1,

2,

3,

4} , Bo He _{1,

2,

3,

4} , Shu-Qin Gao _{2,

3,

4,

5} , Ge-Bo Wen _{2,

3,

4,

5} , Ying-Wu Lin _{1,

2,

3,

4,

5}

Affiliation

Myoglobin with a redesigned active center was constructed and reconstituted with zinc protoporphyrin (ZnPP), which was shown to exhibit novel photo-induced DNA cleavage activities, involving a hydroxyl radical (˙OH) with a minor contribution from singlet oxygen (¹O₂), as confirmed by spin-trapping studies for the first time.

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