Guanidinium-based “molecular glues” for modulation of biomolecular functions,Chemical Society Reviews

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Guanidinium-based “molecular glues” for modulation of biomolecular functions
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2017-10-16 00:00:00 , DOI: 10.1039/c7cs00647k
Rina Mogaki _{1,

2,

3} , P. K. Hashim _{1,

2,

3} , Kou Okuro _{1,

2,

3} , Takuzo Aida _{1,

2,

3,

4,

5}

Affiliation

Molecular adhesion based on multivalent interactions plays essential roles in various biological processes. Hence, “molecular glues” that can adhere to biomolecules may modulate biomolecular functions and therefore can be applied to therapeutics. This tutorial review describes design strategies for developing adhesive motifs for biomolecules based on multivalent interactions. We highlight a guanidinium ion-based salt-bridge as a key interaction for adhesion to biomolecules and discuss the application of molecular glues for manipulation of biomolecular assemblies, drug delivery systems, and modulation of biomolecular functions.

中文翻译：

基于胍盐的“分子胶”可调节生物分子功能

基于多价相互作用的分子粘附在各种生物学过程中起着至关重要的作用。因此，可以粘附于生物分子的“分子胶”可以调节生物分子的功能，因此可以应用于治疗。本教程概述描述了基于多价相互作用为生物分子开发粘性基序的设计策略。我们重点介绍了基于胍盐离子的盐桥作为粘附至生物分子的关键相互作用，并讨论了分子胶在生物分子组装，药物递送系统和生物分子功能调节中的应用。

更新日期：2017-10-30

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