Biocompatible conjugated polymer nanoparticles for highly efficient photoacoustic imaging of orthotopic brain tumors in the second near-infrared window,Materials Horizons

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Biocompatible conjugated polymer nanoparticles for highly efficient photoacoustic imaging of orthotopic brain tumors in the second near-infrared window
Materials Horizons ( IF 13.3 ) Pub Date : 2017-09-26 00:00:00 , DOI: 10.1039/c7mh00672a
Bing Guo _{1,

2,

3,

3} , Zonghai Sheng _{4,

5,

6,

7,

8} , Kenry Kenry _{1,

2,

3,

3} , Dehong Hu _{4,

5,

6,

7,

8} , Xiangwei Lin _{5,

6,

7,

9,

10} , Shidang Xu _{1,

2,

3,

3} , Chengbo Liu _{5,

6,

7,

9,

10} , Hairong Zheng _{4,

5,

6,

7,

8} , Bin Liu _{1,

2,

3,

3}

Affiliation

A new second near-infrared (NIR II) conjugated polymer (CP) was designed and synthesized. The CP nanoparticles have good biocompatibility, excellent photostability and high imaging contrast, and have been successfully used to demonstrate the first example of NIR II photoacoustic imaging of orthotopic brain tumors. In comparison with existing contrast agents for photoacoustic imaging, the NIR II CP nanoparticles showed more efficient skull penetration and a much higher signal/background ratio using a 1064 nm laser.

中文翻译：

生物相容性共轭聚合物纳米颗粒，用于在第二个近红外窗口中对原位脑肿瘤进行高效的光声成像

设计并合成了一种新的第二种近红外（NIR II）共轭聚合物（CP）。CP纳米粒子具有良好的生物相容性，出色的光稳定性和较高的成像对比度，并已成功用于证明原位脑肿瘤的NIR II光声成像的第一个实例。与用于光声成像的现有造影剂相比，使用1064 nm激光，NIR II CP纳米颗粒显示出更有效的颅骨穿透力和更高的信号/背景比。

更新日期：2017-10-30

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