The outermost cell layer of plant roots (epidermis) constantly encounters environmental challenges. The epidermal outer plasma membrane domain harbours the PENETRATION3 (PEN3)/ABCG36/PDR8 ATP-binding cassette transporter that confers non-host resistance to several pathogens. Here, we show that the Arabidopsis ENDOPLASMIC RETICULUM-ARRESTED PEN3 (EAP3) BTB/POZ-domain protein specifically mediates PEN3 exit from the endoplasmic reticulum and confers resistance to a root-penetrating fungus, providing prime evidence for BTB/POZ-domain protein-dependent membrane trafficking underlying disease resistance.

中文翻译：

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拟南芥BTB / POZ蛋白依赖性PENETRATION3贩运和疾病易感性。

植物根部（表皮）的最外层细胞层不断遇到环境挑战。表皮外质膜域带有PENETRATION3（PEN3）/ ABCG36 / PDR8 ATP结合盒转运蛋白，赋予非宿主抗几种病原体的能力。在这里，我们显示拟南芥内窥镜网状阻止PEN3（EAP3）BTB / POZ域蛋白特异性介导PEN3从内质网退出并赋予对穿透根真菌的抗性，为BTB / POZ域蛋白-依赖膜运输的潜在疾病抗性。