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Distinct kinetics of serine and threonine dephosphorylation are essential for mitosis
Nature Cell Biology ( IF 21.3 ) Pub Date : 2017-10-30 , DOI: 10.1038/ncb3634
Jamin B. Hein , Emil P. T. Hertz , Dimitriya H. Garvanska , Thomas Kruse , Jakob Nilsson

Distinct kinetics of serine and threonine dephosphorylation are essential for mitosis

Nature Cell Biology, Published online: 30 October 2017; doi:10.1038/ncb3634

Cdk1-mediated phosphorylation of threonine and serine residues on cell cycle regulators needs to be removed after mitosis. Hein et al. show that the known preference of the PP2A–B55 phosphatase for threonine provides temporal regulation of mitotic exit.



中文翻译:

丝氨酸和苏氨酸去磷酸化的不同动力学对于有丝分裂至关重要

丝氨酸和苏氨酸去磷酸化的不同动力学对于有丝分裂至关重要

《自然细胞生物学》(Nature Cell Biology),在线发布:2017年10月30日;doi:10.1038 / ncb3634

在有丝分裂后需要清除细胞周期调节剂上Cdk1介导的苏氨酸和丝氨酸残基的磷酸化。Hein等。表明已知的PP2A–B55磷酸酶对苏氨酸的偏好提供了有丝分裂出口的时间调控。

更新日期:2017-10-30
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