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Modelling diabetic nephropathy in mice
Nature Reviews Nephrology ( IF 28.6 ) Pub Date : 2017-10-24 , DOI: 10.1038/nrneph.2017.142 Kengo Azushima , Susan B. Gurley , Thomas M. Coffman
Nature Reviews Nephrology ( IF 28.6 ) Pub Date : 2017-10-24 , DOI: 10.1038/nrneph.2017.142 Kengo Azushima , Susan B. Gurley , Thomas M. Coffman
Modelling diabetic nephropathy in mice
中文翻译:
在小鼠中建模糖尿病性肾病
在小鼠中建模糖尿病性肾病
更新日期:2017-10-30
Nature Reviews Nephrology, Published online: 24 October 2017; doi:10.1038/nrneph.2017.142
Animal models that faithfully recapitulate human diabetic nephropathy (DN) are needed to study disease pathogenesis, identify drug targets and test new therapies. Here, the authors review progress in developing mouse models of DN, the limitations of current models, and opportunities for future development.
中文翻译:
在小鼠中建模糖尿病性肾病
在小鼠中建模糖尿病性肾病
Nature Reviews Nephrology,在线发布:2017年10月24日;doi:10.1038 / nrneph.2017.142
需要忠实地概括人类糖尿病肾病(DN)的动物模型来研究疾病的发病机制,确定药物靶标并测试新疗法。在这里,作者回顾了DN小鼠模型的开发进展,当前模型的局限性以及未来的发展机会。